Mesalamine
 
What is Mesalamine and why is it prescribed?
Mesalamine is used to treat mild to moderate ulcerative colitis. Mesalamine is also prescribed for inflammation of the lower colon, and inflammation of the rectum. Mesalamine has been known to cause side effects such as: Bloody diarrhea, Cramping, Fever, Rash, Severe headache, and Sudden, severe stomach pain. If you develop any of these symptoms, stop taking this medication and consult your doctor.

How should you take Mesalamine?
Follow your doctors directions for taking Mesalamine. To use Mesalamine Suspension Enema (1) Mesalamine Suspension Enema comes in boxes of 7 bottles each. After the foil on the box has been unwrapped, all Mesalamine Suspension Enemas should be used promptly, following your doctor's instructions. The Suspension Enema is normally off-white to tan in color, but may darken over time once its foil cover is unwrapped. You may still use the enema if it is slightly discolored, but do not use Mesalamine Suspension Enema if it is dark brown. If you have any questions about using Mesalamine Suspension Enema, contact your doctor, (2) Use Mesalamine Suspension Enema at bedtime, (3) Shake the bottle thoroughly, (4) Uncover the applicator tip, (5) You may find it easier to use Rowasa Suspension Enema if you lie down on your left side, extending your left leg and bending your right leg forward for a comfortable balance. An alternative position is on your knees with your hips in the air and your head and shoulders down on the bed, (6) Pointing the applicator tip slightly towards the navel, gently insert the tip into the rectum, (7) Tilt the bottle slightly towards the back, then squeeze it slowly to discharge the contents, and (8) Remain in position for at least 30 minutes to allow thorough distribution of the medicine. Retain the enema all night (8 hours) for best results. To use Mesalamine Suppositories (1) Mesalamine Suppositories should be used twice a day, (2) You should handle the suppositories as little as possible, because they are designed to melt at body temperature, (3) Remove one suppository from the strip of suppositories, (4) While holding the suppository upright, carefully remove the wrapper, (5) Using gentle pressure, insert the suppository (with the pointed end first) completely into the rectum. A small amount of lubricating gel may be used on the tip of the suppository to assist insertion, and (6) The suppository should be retained for 1 to 3 hours or longer for best results. If you miss a dose take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take two doses at the same time. Store these products at room temperature. Keep suppositories away from direct heat, light, and humidity. Do not refrigerate.

Are there any Mesalamine side effects?
Mesalamine side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. More common Mesalamine side effects generally include diarrhea, dizziness, flu-like symptoms, gas, headache, nausea, and stomach pain. Other typical Mesalamine side effects may include abdominal pain, acne, back pain, belching, bloating, chest pain, chills, constipation, fever, hair loss, hemorrhoids, indigestion, insomnia, itching, joint pain, leg pain, liver disorders, menstrual problems, muscle pain, nasal inflammation, rash, rectal pain or bleeding, sore throat, stomach and intestinal bleeding, sweating, swelling of the arms and legs, tiredness, urinary burning, vomiting, and weakness. Although quite rare, other problems are possible. If you notice any unusual symptoms, check with your doctor.

What are the possible food and drug interactions when taking Mesalamine?
If Mesalamine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Be sure to inform your doctor of all the prescription and over the counter medications you are taking. It is especially important to check with your doctor before combining Mesalamine with sulfasalazine (Azulfidine).

Are there any special warnings about Mesalamine?
Your doctor should check your kidney function while you are taking Mesalamine, especially if you have a history of kidney disease or you are using other anti-inflammatory drugs such as Dipentum. Because older adults tend to have weaker kidneys, Mesalamine is more likely to trigger side effects within this age group. The drug also seems more prone to cause blood disorders in older adults. If you are 65 or older, be sure to tell the doctor about any change in your health. You should use Mesalamine cautiously if you are allergic to sulfasalazine (Azulfidine). If you develop a rash or fever, you should stop using the medication and notify your doctor. Some people using Mesalamine have developed flare-ups of their colitis. Inflammation of the pancreas has also been reported. Rare cases of pericarditis, in which the membrane surrounding the heart becomes inflamed, have been reported with products containing Mesalamine. Symptoms may include chest, neck, and shoulder pain, and shortness of breath. Mesalamine Suspension Enema contains a sulfite that may cause allergic reactions in some people. These reactions may include shock and severe, possibly fatal asthma attacks. Most people aren't sensitive to sulfites. However, some people with asthma might be sensitive and should take any medication containing sulfites cautiously. Mesalamine Suspension Enema may stain clothes and fabrics.
 

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