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Sinemet CR |
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What is Sinemet CR and why is it prescribed? Sinemet CR is a controlled-release tablet that may be given to help relieve the muscle stiffness, tremor, and weakness caused by Parkinson's disease. It may also be given to relieve Parkinson-like symptoms caused by encephalitis, carbon monoxide poisoning, or manganese poisoning. Sinemet CR contains two drugs, carbidopa and levodopa. The drug that actually produces the anti-Parkinson's effect is levodopa. Carbidopa prevents vitamin B6 from destroying levodopa, thus allowing levodopa to work more efficiently. Parkinson's drugs such as Sinemet CR relieve the symptoms of the disease, but are not a permanent cure. There is also a regular, non-controlled-release form of this medication, which is called Sinemet. Over a period of hours, Sinemet CR, the controlled-release form, gives a smoother release of the drug than regular Sinemet. If you have been taking regular Sinemet, be aware that you may need a somewhat higher dosage of Sinemet CR to get the same degree of relief. Your first morning dose of Sinemet CR may take as much as an hour longer to start working than your first morning dose of regular Sinemet. How should you take Sinemet CR? Follow your doctors directions for taking Sinemet CR. Take Sinemet CR after meals, rather than before or between meals. Swallow the tablets whole without chewing or crushing them. Sinemet CR releases its ingredients slowly over a period of 4 to 6 hours. It is important to follow a careful schedule, taking your doses at the same time every day. You should not change the prescribed dosage or add another product for Parkinson's disease without first consulting your doctor. Sinemet CR works best when there is a constant amount in the blood. Try not to miss any doses, and take them at evenly spaced intervals day and night. If you miss a dose take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take two doses at once. Store Sinemet CR at room temperature in a tightly closed container. Are there any Sinemet CR side effects? Sinemet CR side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. More common Sinemet CR side effects may include confusion, hallucinations, nausea, and uncontrollable twitching or jerking. Less common or rare Sinemet CR side effects may include abdominal or stomach pain, abnormal dreams, agitation, anemia, anxiety, back pain, bizarre breathing patterns, bleeding from stomach, blisters, blurred vision, burning sensation of tongue, chest pain, clumsiness in walking, common cold, constipation, convulsions, cough, dark saliva, dark sweat, dark urine, delusions, depression, diarrhea, dilated pupils, disorientation, dizziness, dizziness upon rising from a sitting or lying position, double vision, dream abnormalities, drooling, drowsiness, dry mouth, euphoria, eyelid twitching, faintness, falling, fatigue, fever, flatulence, fluid retention, flushing, hair loss, headache, heart attack, heart palpitations, heartburn, hiccups, high or low blood pressure, hoarseness, hot flashes, increased sex drive, increased tremor, insomnia or other sleep problems, irregular heartbeat, leg pain, locked jaw, loss of appetite, malignant melanoma, memory problems, mental changes, muscle cramps, muscle twitching, nervousness, numbness, "on-off" phenomena, paralysis of certain muscles and unwanted movement of others, paranoia, persistent erection, phlebitis, rash, rolling eyes, shortness of breath, shoulder pain, slowed physical movements, sore throat, speech impairment, stomach ulcer, suicidal tendencies, swallowing difficulties, sweating, taste changes, teeth-grinding, tingling or pins and needles, upper respiratory infection, upset stomach, urinary frequency, urinary incontinence, urinary retention, urinary tract infections, weakness, weight loss or gain, writhing or flailing movements, and vomiting. What are the possible food and drug interactions when taking Sinemet CR? If Sinemet CR is taken with certain other drugs, the effects of either could be increased, decreased, or altered. Be sure to inform your doctor of all the prescription and over the counter medications you are taking. It is especially important to check with your doctor before combining Sinemet CR with Antacids (such as Di-Gel, Maalox, and Mylanta), Antiseizure drugs (such as Dilantin), Antispasmodic drugs (such as Artane and Cogentin), Antihypertensives (such as Aldomet and Clonidine), High-protein foods, Isoniazid (Nydrazid), Major tranquilizers (such as Haldol, Mellaril, Risperdal, and Thorazine), MAO inhibitors (such as the antidepressants Nardil and Parnate and the Parkinson's drug Eldepryl), Methionine drugs (such as Pedameth), Metoclopramide (Reglan), Papaverine (Pavabid), Pyridoxine (Vitamin B6), Tranquilizers (such as Dalmane, Valium, and Xanax), or Tricyclic antidepressants (such as Elavil and Tofranil). If you have been taking an MAO inhibitor such as Nardil or Parnate, you must discontinue it at least 2 weeks before starting to take Sinemet CR. A high-protein diet may impair the effectiveness of Sinemet CR. Iron supplements can also reduce its effect. Are there any special warnings about Sinemet CR? Make sure your doctor knows if you have any of the following: Bronchial asthma, Cardiovascular or lung disease (severe), Endocrine (glandular) disorder, History of heart attack or heartbeat irregularity, History of active peptic ulcer, Kidney disorder, Liver disorder, or Wide-angle glaucoma. Your doctor will monitor your liver, blood, kidney and heart functions during extended therapy with Sinemet CR. If you have been taking levodopa alone, you should stop taking levodopa for at least 12 hours before starting to take Sinemet CR. The carbidopa contained in Sinemet CR cannot eliminate side effects caused by levodopa. Since carbidopa helps levodopa reach your brain, Sinemet CR may, in fact, produce some levodopa side effects, particularly twitching, jerking, or writhing, sooner and at a lower dosage than levodopa alone or even regular Sinemet. If such involuntary movements develop while you are taking Sinemet CR, you may need a dosage reduction. Like levodopa, Sinemet CR may cause depression. Make sure your doctor knows if you have mental or emotional problems. Muscle rigidity, high temperature, rapid heartbeat or breathing, sweating, blood pressure changes, and mental changes may occur when Sinemet CR is reduced suddenly or discontinued. If you stop taking this medication abruptly, your doctor should monitor your condition carefully. You may see a red, brown, or black coloration in your saliva, urine, or sweat. This is not harmful, but may stain your clothes. Too much stomach acid can interfere with absorption of Sinemet CR. |
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